Description

Cyclopamine CAS NO 4449-51-8 is a potent, naturally occurring steroidal alkaloid known for its specific inhibitory activity against the Hedgehog (Hh) signaling pathway. This unique mechanism of action makes it an invaluable research tool for studying developmental biology, tissue regeneration, and oncogenesis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer research, stem cell studies, and targeted therapy development.

Application

• Biomedical Research: A critical chemical probe for investigating the Hedgehog signaling pathway's role in embryonic development and cellular differentiation.
• Oncology Studies: Used in vitro and in vivo to inhibit Hh-dependent tumor growth, making it essential for cancer mechanism research and preclinical drug discovery.
• Stem Cell Research: Employed to modulate signaling pathways that control stem cell fate and proliferation in regenerative medicine studies.
• Pharmacological Tool Compound: Serves as a reference standard and active agent in high-throughput screening assays and target validation.
• Biochemical Pathway Analysis: Used to dissect complex signaling networks and understand crosstalk in developmental and disease models.
• Reference Standard: Provides a high-purity benchmark for analytical methods, quality control, and metabolic studies in research settings.

Basic Information

Product Name	Cyclopamine
CAS No.	4449-51-8
Molecular Formula	C27H41NO2
Molecular Weight	411.62 g/mol
Synonyms	11-Deoxojervine; (3β,23R)-17,23-Epoxy-11-deoxojervan-3-ol; 3β-Hydroxy-11-deoxojervine; Jervine, 11-deoxy-; 11-Deoxyjervine; Cyclopamine (Veroatrum alkaloid); NSC 254681; K 106-148
EINECS	Contact for details

Quality Control

Our Cyclopamine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, Ethanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.