Description

Desmethylnortriptyline is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant nortriptyline. This compound is of significant value in analytical chemistry and pharmaceutical research for method development, quality control, and metabolic studies. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in the development and testing of neuroactive drugs.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of nortriptyline and related compounds in drug substances and finished products.
• Metabolite Studies: Used in pharmacokinetic and pharmacodynamic research to understand the metabolic pathways and biological activity of nortriptyline.
• Analytical Method Development: Critical for developing and validating chromatographic methods (HPLC, LC-MS) in bioanalytical and quality control laboratories.
• Impurity Profiling: Employed as an impurity marker to monitor and control the quality of active pharmaceutical ingredients (APIs) during synthesis and purification processes.
• Clinical Toxicology: Acts as a calibrant in forensic and clinical toxicology for the accurate detection and quantification of tricyclic antidepressants in biological samples.
• Biochemical Research: Used in vitro studies to investigate the mechanisms of action and side-effect profiles associated with tricyclic antidepressant therapy.

Basic Information

Product Name	Desmethylnortriptyline
CAS No.	4444-42-2
Molecular Formula	C₁₈H₂₁N
Molecular Weight	251.37 g/mol
Synonyms	10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene; 5-(3-Methylaminopropyl)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene; Nortriptyline Impurity C; Nortriptyline Metabolite; Desmethylnortriptyline Hydrochloride (salt form); DMNT; Nor-Nortriptyline
EINECS	Contact for details

Quality Control

Our Desmethylnortriptyline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents to ensure it meets high-purity standards suitable for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.