Description

4-(1-Methylethyl)Benzenesulfonyl Fluoride is a specialized organosulfur fluorinating reagent with a CAS number of 4365-11-1. This compound is valued for its high reactivity as a sulfonyl fluoride donor, making it a critical intermediate in advanced organic synthesis and pharmaceutical research. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs.
• Chemical Biology Probe: Used in activity-based protein profiling (ABPP) and covalent inhibitor development due to its specific reactivity with serine hydrolases and other nucleophilic residues.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents with sulfonyl fluoride motifs.
• Polymer Chemistry: Monomer or cross-linking agent for creating specialty polymers with unique surface properties or chemical resistance.
• Material Science Research: Used in surface functionalization and the development of novel covalent organic frameworks (COFs) or metal-organic frameworks (MOFs).
• Fluorination Reagent: Serves as a source of the sulfonyl fluoride group in medicinal chemistry for improving metabolic stability and membrane permeability of drug candidates.

Basic Information

Product Name	4-(1-Methylethyl)Benzenesulfonyl Fluoride
CAS No.	4365-11-1
Molecular Formula	C9H11FO2S
Molecular Weight	202.25 g/mol
Synonyms	p-Isopropylbenzenesulfonyl Fluoride; 4-Isopropylbenzenesulfonyl Fluoride; Cumene-4-sulfonyl Fluoride; (4-Isopropylphenyl)sulfonyl Fluoride; 1-Isopropyl-4-fluorosulfonylbenzene; Isopropylphenylsulfonyl Fluoride; IPSF
EINECS	Contact for details

Quality Control

Our 4-(1-Methylethyl)Benzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and highly volatile compound, keep away from heat, sparks, and open flames. Isolate from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density	~1.25 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.