Description

Necrostatin-1 CAS NO 4311-88-0 is a potent and selective small-molecule inhibitor of necroptosis, a form of programmed cell death. This compound is a critical research tool for investigating cell death pathways and their role in various disease models. It is primarily utilized by researchers and scientists in the fields of pharmaceutical development, academic research, and biotechnology for target validation and mechanistic studies.

Application

• Biomedical Research: Fundamental studies on the molecular mechanisms of necroptosis and its distinction from apoptosis.
• Drug Discovery: A key pharmacological tool for validating RIPK1 (Receptor-interacting serine/threonine-protein kinase 1) as a therapeutic target in high-throughput screening assays.
• Disease Modeling: Used in research models for ischemic injury (e.g., stroke, myocardial infarction), neurodegenerative diseases, and inflammatory conditions to assess the role of necroptosis.
• Cell Biology: Employed in *in vitro* cell culture experiments to protect cells from TNF-α-induced necroptotic death.
• Preclinical Studies: Investigation of therapeutic potential in animal models of tissue damage and systemic inflammatory response syndrome (SIRS).

Basic Information

Product Name	Necrostatin-1
CAS No.	4311-88-0
Molecular Formula	C₁₃H₁₃N₃O₂S
Molecular Weight	275.33 g/mol
Synonyms	5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec-1; Necrostatin 1; 5-[(1H-Indol-3-yl)methyl]-3-methyl-2-sulfanylideneimidazolidin-4-one; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; RIPK1 Inhibitor
EINECS	Contact for details

Quality Control

Our Necrostatin-1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.