Description

Hemicholinium-15 is a potent and selective inhibitor of the high-affinity choline uptake (HACU) system. This compound is a critical research tool for studying cholinergic neurotransmission, synaptic function, and related neurological pathways. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical researchers investigating mechanisms of memory, learning, and neurodegenerative conditions.

Application

• Neuroscience Research: A key pharmacological agent for selectively blocking choline transport in presynaptic neurons, facilitating studies on acetylcholine synthesis and release.
• Neuropharmacology: Used to investigate the cholinergic system's role in cognitive functions, memory formation, and potential therapeutic targets for cognitive disorders.
• Biochemical Assays: Serves as a reference standard and active compound in in vitro and ex vivo assays to quantify high-affinity choline uptake activity.
• Drug Discovery: Employed in screening platforms and mechanistic studies to evaluate new compounds targeting the cholinergic pathway for neurological and psychiatric diseases.
• Toxicology Studies: Used to model cholinergic hypofunction and understand the effects of neurotoxins that impair cholinergic transmission.

Basic Information

Product Name	Hemicholinium-15
CAS No.	4303-88-2
Molecular Formula	C₂₄H₃₂Br₂N₂O₄
Molecular Weight	572.34 g/mol
Synonyms	HC-15; Hemicholinium 15; Hemicholinium-3 Bromide; 2,2'-(4,4'-Biphenylylene)bis(2-hydroxy-4,4-dimethylmorpholinium) Dibromide; 4,4'-Biphenylenebis(2-hydroxy-4,4-dimethylmorpholinium) Dibromide; NSC 114939; 1,1'-(1,1'-Biphenyl)-4,4'-diylbis[2-hydroxy-4,4-dimethylmorpholinium]dibromide
EINECS	Contact for details

Quality Control

Our Hemicholinium-15 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.