Description

Desethyl Hydroxy Chloroquine is a key pharmaceutical intermediate and metabolite of the antimalarial drug hydroxychloroquine. This compound is of significant importance for research and development in pharmacology and analytical chemistry, particularly in metabolic pathway studies and bioanalytical method validation. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) research, impurity profiling, and reference standard preparation.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of hydroxychloroquine and its related substances in drug products and biological matrices.
• Metabolite Studies: Critical for in-vitro and in-vivo DMPK research to understand the biotransformation, clearance, and activity of hydroxychloroquine.
• Impurity Profiling: Used as an analytical standard to identify, quantify, and control desethyl hydroxy chloroquine as a potential degradation product or process-related impurity in active pharmaceutical ingredient (API) manufacturing.
• Bioanalytical Method Development: Essential for developing and validating sensitive LC-MS/MS or HPLC methods for therapeutic drug monitoring and clinical trial sample analysis.
• Pharmacological Research: Employed in studies to investigate the individual contribution of this metabolite to the overall efficacy and safety profile of hydroxychloroquine therapy.

Basic Information

Product Name	Desethyl Hydroxy Chloroquine
CAS No.	4298-15-1
Molecular Formula	C₁₈H₂₆ClN₃O
Molecular Weight	335.87 g/mol
Synonyms	4-[(7-Chloro-4-quinolyl)amino]-2-[(1-hydroxyethyl)amino]pentane; N-Desethylhydroxychloroquine; Hydroxychloroquine Desethyl Metabolite; 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl](ethyl)amino]ethanol (related); HCQ Desethyl Metabolite; Desethyl Hydroxychloroquine Sulfate (salt form); DE-HCQ
EINECS	Contact for details

Quality Control

Our Desethyl Hydroxy Chloroquine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order to ensure traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.