Description

p-Tolylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its primary value lies in its ability to act as a powerful nucleophile, introducing the p-tolyl group into a diverse array of electrophilic substrates. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures and fine chemical intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing substituted biphenyl or diarylmethane cores.
• Agrochemical Production: Used in the manufacture of herbicides, fungicides, and pesticides where the p-tolyl moiety imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers by incorporating aromatic tollyl units.
• Fine Chemical and Flavor/Fragrance Synthesis: Facilitates the production of high-value aromatic compounds used in specialty chemicals.
• Cross-Coupling Reactions: A crucial reagent in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling methodologies.

Basic Information

Product Name	p-Tolylmagnesium Bromide
CAS No.	4294-57-9
Molecular Formula	C7H7BrMg
Molecular Weight	195.34 g/mol
Synonyms	4-Methylphenylmagnesium Bromide; (4-Methylphenyl)magnesium Bromide; p-Tolylmagnesium Bromide solution; 4-Tolylmagnesium Bromide; Magnesium, bromo(4-methylphenyl)-; p-Methylphenylmagnesium Bromide; Grignard Reagent p-TolylMgBr; Bromo(4-methylphenyl)magnesium
EINECS	Contact for details

Quality Control

Our p-Tolylmagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm concentration, purity, and suitability for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing assay (by titration), solvent content, and other critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and typically supplied as a solution in ether or THF. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures, usually between 2°C to 8°C for extended stability. Keep away from heat, sparks, open flames, and strong oxidizers. Use appropriate ventilation and equipment rated for pyrophoric/air-sensitive materials.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration	Typically 0.5 M to 2.0 M in specified solvent (e.g., THF, Diethyl ether)
Assay (Titration)	≥ 95% of stated concentration
Identification (IR)	Conforms to structure
Solvent (GC)	As specified (e.g., Tetrahydrofuran, Diethyl ether)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.