Description

Tlck CAS NO 4272-74-6 is a specific and potent inhibitor of serine proteases, particularly trypsin-like enzymes, widely utilized in biochemical research and pharmaceutical development. This compound is critical for studying protease function, enzyme kinetics, and for developing targeted therapeutic agents. It serves as an essential tool for researchers and manufacturers in the fields of proteomics, drug discovery, and diagnostic assay development.

Application

• Biochemical Research: As a selective inhibitor for mechanistic studies of serine proteases like trypsin, thrombin, and plasmin.
• Pharmaceutical R&D: Used in high-throughput screening and validation of novel drug candidates targeting protease pathways.
• Diagnostic Reagent Formulation: A key component in diagnostic kits for clinical analysis of blood coagulation and fibrinolysis.
• Cell Culture & Proteomics: Employed to control proteolytic activity in cell lysates and protein purification processes.
• Enzyme Engineering: Serves as a reference standard for evaluating the efficacy and specificity of engineered proteases.

Basic Information

Product Name	Tlck
CAS No.	4272-74-6
Molecular Formula	C14H22ClN5O2S
Molecular Weight	367.88 g/mol
Synonyms	TLCK; Tosyl-L-lysyl-chloromethane hydrochloride; Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride; TLCK hydrochloride; L-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride; TLCH; Antipain; Trypsin inhibitor TLCK; Protease inhibitor TLCK
EINECS	224-250-3

Quality Control

Our Tlck is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in water, DMSO, methanol
Biological Activity	≥ 95% inhibition of trypsin at specified concentration

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.