Description

Despiro-Cyclopamine is a synthetic derivative of the natural alkaloid cyclopamine, designed for enhanced stability and specific biological activity. This compound is a critical research-grade chemical for investigating developmental signaling pathways, particularly the Hedgehog (Hh) pathway. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, developmental biology, and targeted therapeutic discovery.

Application

• Biomedical Research: A key tool compound for studying the inhibition of the Hedgehog (Hh) signaling pathway in cellular and molecular biology experiments.
• Oncology Research: Used in preclinical studies to investigate the role of Hh pathway dysregulation in various cancers, including basal cell carcinoma and medulloblastoma.
• Developmental Biology Studies: Employed to model and understand congenital disorders and embryonic development processes influenced by the Hh pathway.
• High-Throughput Screening (HTS): Serves as a reference standard or active control in drug discovery campaigns targeting smoothened (SMO) receptor antagonists.
• Biochemical Assay Development: Used to validate and optimize in vitro assays designed to measure Hh pathway activity.
• Pharmacology & Toxicology Studies: Utilized in ADME (Absorption, Distribution, Metabolism, Excretion) and safety profiling of novel Hh pathway inhibitors.

Basic Information

Product Name	Despiro-Cyclopamine
CAS No.	4243-43-0
Molecular Formula	C27H41NO2
Molecular Weight	411.62 g/mol
Synonyms	11-Deoxojervine; (3β,23R)-17,23-Epoxy-3-hydroxyveratraman-11-one; 22,26-Imino-5α-cholestan-3β-ol-11-one; 11-Oxojervine; Despirocyclopamine; Cyclopamine derivative; Jervine analog; Hedgehog pathway inhibitor-1 (HPI-1) analog
EINECS	Contact for details

Quality Control

Our Despiro-Cyclopamine CAS NO 4243-43-0 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.