Description

4-Iodobenzenesulfonyl Fluoride is a versatile and highly reactive organofluorine building block, specifically a sulfonyl fluoride derivative. Its unique structure, featuring both an iodine substituent and a sulfonyl fluoride group, makes it a critical intermediate for constructing complex molecules in medicinal chemistry and materials science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise functionalization and cross-coupling capabilities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs via sulfur(VI) fluoride exchange (SuFEx) click chemistry.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the iodine atom allows for further palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probe Development: Serves as a reactive handle for labeling proteins and biomolecules, enabling activity-based protein profiling (ABPP) and proteomics research.
• Polymer & Materials Science: Employed as a monomer or cross-linking agent to introduce sulfonyl fluoride functionalities into polymers, creating materials with specific surface properties or reactivity.
• Organic Synthesis Reagent: Facilitates various transformations, including Suzuki-Miyaura and other palladium-catalyzed couplings, leveraging the aryl iodide moiety.
• Ligand & Catalyst Preparation: Used to synthesize sophisticated ligands for catalysis or as a precursor for metal-organic frameworks (MOFs) and other advanced materials.

Basic Information

Product Name	4-Iodobenzenesulfonyl Fluoride
CAS No.	4241-66-1
Molecular Formula	C6H4FIO2S
Molecular Weight	286.06 g/mol
Synonyms	p-Iodobenzenesulfonyl Fluoride; Benzenesulfonyl Fluoride, 4-iodo-; 4-Iodophenylsulfonyl Fluoride; 1-Iodo-4-(fluorosulfonyl)benzene; 4241-66-1; 4-Iodo-benzenesulfonyl fluoride; 4-Iodobenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 4-Iodobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.