Description

Tlck CAS NO 4238-41-9 is a highly specific and potent synthetic inhibitor of serine proteases, particularly trypsin-like enzymes. This compound is critical for biochemical research and pharmaceutical development, enabling precise control and study of proteolytic activity. It is primarily utilized by research institutions, diagnostic kit manufacturers, and biopharmaceutical companies engaged in enzyme mechanism studies, drug discovery, and the development of therapeutic agents targeting protease-related pathways.

Application

• Biochemical Research: As a selective and irreversible inhibitor for mechanistic studies of serine proteases like trypsin, thrombin, and plasmin.
• Pharmaceutical Development: Used in drug discovery programs targeting conditions involving abnormal protease activity, such as thrombosis, inflammation, and cancer metastasis.
• Diagnostic Reagent Formulation: Incorporated into in-vitro diagnostic (IVD) kits and assays to selectively inhibit specific proteases and ensure test accuracy.
• Cell Culture & Proteomics: Employed to prevent unwanted proteolytic degradation during cell line maintenance or protein sample preparation.
• Enzyme Purification: Acts as an affinity ligand or elution agent in the purification of specific serine proteases.
• Reference Standard: Serves as a high-purity analytical standard for quality control in related pharmaceutical and research applications.

Basic Information

Product Name	Tlck
CAS No.	4238-41-9
Molecular Formula	C14H22Cl2N4O2
Molecular Weight	349.26 g/mol
Synonyms	TLCK; Tosyl-L-lysyl-chloromethane hydrochloride; Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride; TLCK-HCl; L-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride; Nα-p-Tosyl-L-lysine chloromethyl ketone hydrochloride; Antipain (component); Trypsin inhibitor TLCK
EINECS	224-197-9

Quality Control

Our Tlck is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	≥ 95% inhibition of trypsin at specified concentration

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.