Description

(4-Nitrophenyl)Methanesulfonyl Chloride is a high-purity sulfonyl chloride derivative, a key chemical intermediate prized for its reactivity in introducing the methanesulfonyl (mesyl) group. This compound is essential for the synthesis of advanced pharmaceutical ingredients and fine chemicals, where precise functionalization is critical. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active compounds and materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides that require the mesyl functional group for bioactivity.
• Peptide Chemistry: Serves as a sulfonylation reagent for protecting groups or for modifying amino acid side chains in peptide synthesis.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Cross-Coupling Reactions: Acts as a substrate or reagent in palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	(4-Nitrophenyl)Methanesulfonyl Chloride
CAS No.	4025-75-6
Molecular Formula	C7H6ClNO4S
Molecular Weight	235.64 g/mol
Synonyms	p-Nitrophenyl Methanesulfonate Chloride; 4-Nitrophenylmethanesulfonyl Chloride; 1-(Chlorosulfonyl)-1-methoxy-4-nitrobenzene; Methanesulfonyl chloride, (4-nitrophenyl)-; Mesyl chloride, 4-nitrophenyl-; NSC 401119; (p-Nitrophenyl)methanesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (4-Nitrophenyl)Methanesulfonyl Chloride is manufactured and tested under strict quality management protocols to ensure consistency and high purity for research and production applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.