Description

4-Hydroxy-Benzenesulfonyl Chloride is a key aromatic sulfonyl chloride derivative, serving as a versatile and reactive chemical intermediate. Its primary value lies in its ability to introduce the sulfonyl functional group into target molecules, enabling the synthesis of more complex compounds. This product is essential for research and industrial-scale manufacturing within the pharmaceutical, agrochemical, and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing sulfonamide drugs, including diuretics, antibacterial agents, and protease inhibitors.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that contain sulfonylurea or sulfonamide moieties.
• Dye and Pigment Manufacturing: Acts as a reactant in the synthesis of sulfonated dyes and optical brighteners.
• Polymer Modification: Employed to introduce sulfonyl groups into polymers, altering their solubility, thermal stability, or ionic properties.
• Chemical Research & Development: A valuable reagent in organic synthesis for creating novel sulfonated compounds in academic and industrial R&D labs.
• Cross-coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions to form biaryl sulfones.

Basic Information

Product Name	4-Hydroxy-Benzenesulfonyl Chloride
CAS No.	4025-67-6
Molecular Formula	C6H5ClO3S
Molecular Weight	192.62 g/mol
Synonyms	p-Hydroxybenzenesulfonyl chloride; Phenol-4-sulfonyl chloride; 4-Hydroxybenzene-1-sulfonyl chloride; 4-Hydroxybenzenesulphonyl chloride; p-Phenolsulfonyl chloride; 4-Hydroxybenzenesulfonic acid chloride; (4-Hydroxyphenyl)sulfonyl chloride
EINECS	223-701-8

Quality Control

Our 4-Hydroxy-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade specifications for use as a fine chemical intermediate. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed to prevent decomposition. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	88°C - 92°C
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.