Description

4-Bromobenzenesulfonyl Fluoride is a versatile and highly reactive organosulfur compound that serves as a critical building block in advanced chemical synthesis. Its value lies in the unique combination of the sulfonyl fluoride moiety and the bromine substituent, enabling selective and efficient derivatization. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for constructing complex molecules and developing covalent inhibitors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of sulfonamide-based drugs and covalent enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and other crop protection agents where the sulfonyl fluoride group imparts specific biological activity.
• Chemical Biology & Proteomics: Employed as a probe in activity-based protein profiling (ABPP) and for developing targeted covalent inhibitors due to its reactive sulfonyl fluoride group.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced materials with tailored properties.
• Organic Synthesis Reagent: A valuable reagent for introducing the 4-bromobenzenesulfonyl group into molecules via nucleophilic substitution or cross-coupling reactions.
• Ligand & Catalyst Development: Used to create novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Bromobenzenesulfonyl Fluoride
CAS No.	498-83-9
Molecular Formula	C6H4BrFO2S
Molecular Weight	239.06 g/mol
Synonyms	p-Bromobenzenesulfonyl Fluoride; 1-Bromo-4-(fluorosulfonyl)benzene; Benzenesulfonyl fluoride, 4-bromo-; 4-Bromophenylsulfonyl fluoride; 4-Bromo-1-fluorosulfonylbenzene; 4-Bromobenzene-1-sulfonyl fluoride
EINECS	207-870-9

Quality Control

Our 4-Bromobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality assurance ensures the material meets the stringent requirements for research and industrial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.