Description

5-Trifluoromethyl-8-Quinolinamine is a high-value, fluorinated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a quinoline scaffold and a trifluoromethyl group, makes it indispensable for creating compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the research and synthesis of potential drug candidates, particularly in developing molecules for oncology, anti-infective, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to construct advanced fungicides, herbicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, organic semiconductors, and liquid crystals.
• Coordination Chemistry: Acts as a ligand for metal complexes in catalytic applications and materials research due to the nitrogen donor atoms in the quinoline ring.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl moiety into complex molecular architectures in medicinal and synthetic chemistry programs.

Basic Information

Product Name	5-Trifluoromethyl-8-Quinolinamine
CAS No.	483-69-2
Molecular Formula	C10H7F3N2
Molecular Weight	212.17 g/mol
Synonyms	8-Amino-5-(trifluoromethyl)quinoline; 5-(Trifluoromethyl)quinolin-8-amine; 8-Quinolinamine, 5-(trifluoromethyl)-; 5-Trifluoromethyl-8-aminoquinoline; 5-Trifluoromethylquinolin-8-ylamine; 5-CF3-8-Aminoquinoline; 8-Amino-5-trifluoromethylquinoline
EINECS	207-603-9

Quality Control

We maintain stringent quality control protocols for our chemical intermediates. Production of 5-Trifluoromethyl-8-Quinolinamine is monitored through in-process checks and final batch analysis using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.