Description

Bufalin CAS NO 465-21-4 is a potent cardioactive steroid and a primary active component derived from the traditional Chinese medicine Chan Su. It serves as a critical reference standard and active pharmaceutical ingredient (API) for research and development. This compound is essential for scientists and manufacturers in the pharmaceutical and biotechnology sectors, particularly for studies in oncology, cardiology, and signal transduction pathways.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Biomedical Research: A key tool for investigating Na+/K+-ATPase inhibition, cell apoptosis mechanisms, and anti-cancer activity in various cell lines.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis of novel therapeutic agents targeting heart failure and tumors.
• Traditional Medicine Standardization: Employed to standardize and quantify the active components in Chan Su and related herbal preparations.
• Biochemical Assays: Used in enzymatic and receptor-based assays to study ion transport and signal transduction.
• Academic & Institutional Research: Fundamental for pharmacological and toxicological studies in university and research institute laboratories.

Basic Information

Product Name	Bufalin
CAS No.	465-21-4
Molecular Formula	C₂₄H₃₄O₄
Molecular Weight	386.53 g/mol
Synonyms	14,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide; Bufalin; NSC 529070; Bufotalin; 3β,14-Dihydroxy-5β-bufa-20,22-dienolide; 3β-Hydroxy-14,15β-epoxy-5β-bufa-20,22-dienolide; Chan Su constituent
EINECS	Contact for details

Quality Control

Our Bufalin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.