Description

1-Bromo-3,5-Difluorobenzene is a versatile and high-purity halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and materials science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring difluorophenyl or aryl bromide motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysts.
• Material Science Research: Employed in the creation of organic electronic materials, such as semiconductors for OLEDs and OFETs, due to its electron-withdrawing characteristics.
• Fluorinated Liquid Crystal Development: Acts as a core building block for synthesizing fluorinated mesogens used in advanced display technologies.
• Custom Chemical Synthesis: Provides a versatile scaffold for contract research organizations (CROs) and fine chemical companies producing bespoke compounds for client projects.

Basic Information

Product Name	1-Bromo-3,5-Difluorobenzene
CAS No.	461-96-1
Molecular Formula	C6H3BrF2
Molecular Weight	192.99 g/mol
Synonyms	3,5-Difluorobromobenzene; 3,5-Difluorophenyl Bromide; m,m-Difluorobromobenzene; 1-Bromo-3,5-difluorobenzol; Benzene, 1-bromo-3,5-difluoro-; 3-Bromo-1,5-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.7 g/cm³
Boiling Point	~165-168 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.