Description

3-Fluoro-1-Propanesulfonyl Fluoride is a versatile organofluorine building block and sulfonylating agent. Its bifunctional nature, featuring both a reactive sulfonyl fluoride group and a terminal fluorine atom, makes it a critical intermediate for introducing fluorinated sulfonyl motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and advanced materials with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drugs, protease inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science: Precursor for modifying polymer surfaces and creating fluorinated sulfonyl-containing monomers for specialty materials.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands and organocatalysts for asymmetric synthesis.
• Fluorination Reagent: Acts as a source of the fluorosulfonyl group in various fluorination reactions.

Basic Information

Product Name	3-Fluoro-1-Propanesulfonyl Fluoride
CAS No.	461-29-0
Molecular Formula	C3H6F2O2S
Molecular Weight	144.14 g/mol
Synonyms	1-Fluoro-3-(fluorosulfonyl)propane; 3-Fluoropropane-1-sulfonyl fluoride; 3-Fluoropropylsulfonyl fluoride; 1-Propanesulfonyl fluoride, 3-fluoro-; 3-Fluoropropanesulfonyl fluoride; γ-Fluoropropanesulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-1-Propanesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC purity analysis, NMR identification, and water content determination (Karl Fischer), to ensure it meets the highest standards for research and industrial use. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.