Description

3-Fluoro-1-propanesulfonyl chloride is a versatile organofluorine building block and sulfonylating agent. Its value lies in its bifunctional reactivity, where the sulfonyl chloride group enables the introduction of a sulfonamide or sulfonate moiety, and the terminal fluorine atom offers a handle for further structural elaboration. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that incorporate fluorinated sulfonamide groups for enhanced activity and stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and functionalized surfaces.
• Chemical Biology Probes: Employed in the design of activity-based probes and affinity labels to study enzyme function and protein interactions.
• Ligand and Catalyst Development: Useful for preparing fluorinated sulfonamide ligands for metal complexes in catalytic applications.
• Custom Synthesis and R&D: A critical reagent for medicinal chemistry programs and process research in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	3-Fluoro-1-propanesulfonyl Chloride
CAS No.	461-28-9
Molecular Formula	C3H6ClFO2S
Molecular Weight	160.59 g/mol
Synonyms	3-Fluoropropane-1-sulfonyl chloride; 1-Fluoro-3-(chlorosulfonyl)propane; 3-Fluoropropylsulfonyl chloride; γ-Fluoropropanesulfonyl chloride; 3-Fluoro-1-propanesulfonic acid chloride; 461-28-9; 3-Fluoropropanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-1-propanesulfonyl chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay (by GC/HPLC), identity confirmation (IR, NMR), and impurity profiling to ensure high chemical purity and lot-to-lot consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.