Description

(3,3,3-Trifluoropropyl)Magnesium Bromide, 0.50 M In Thf is a versatile organometallic reagent, specifically a Grignard reagent, supplied as a standardized solution in tetrahydrofuran (THF). This compound is a critical building block for the efficient introduction of the 3,3,3-trifluoropropyl group into target molecules, a moiety known to significantly alter physicochemical properties. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing fluorinated bioactive molecules, including active pharmaceutical ingredients (APIs) and drug candidates where the trifluoromethyl group enhances metabolic stability and lipophilicity.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging fluorine's ability to improve biological activity and environmental persistence.
• Advanced Material Precursor: Serves as a monomer or functionalization agent in the production of fluorinated polymers, liquid crystals, and specialty coatings with unique surface properties and chemical resistance.
• Organic Synthesis & Methodology Research: A fundamental tool in academic and industrial R&D for exploring new carbon-carbon bond-forming reactions and developing novel fluorination strategies.
• Electronics & Semiconductor Chemicals: Potential use in the synthesis of fluorinated compounds for dielectric fluids, etchants, or precursors for chemical vapor deposition (CVD).

Basic Information

Product Name	(3,3,3-Trifluoropropyl)Magnesium Bromide, 0.50 M In Thf
CAS No.	461-20-1
Molecular Formula	C3H4F3MgBr
Molecular Weight	201.27 g/mol
Synonyms	3,3,3-Trifluoropropylmagnesium Bromide; 3,3,3-Trifluoropropylmagnesium Bromide Solution; 1,1,1-Trifluoro-3-bromomagnesiopropane; (3,3,3-Trifluoropropyl)magnesium Bromide; Grignard Reagent (3,3,3-Trifluoropropyl)MgBr; 461-20-1; 3-(Trifluoromethyl)propylmagnesium Bromide; Magnesium, bromo(3,3,3-trifluoropropyl)-
EINECS	Contact for details

Quality Control

Our (3,3,3-Trifluoropropyl)Magnesium Bromide solution is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC analysis for solvent purity and by-products, to ensure consistency and reliability. Certificates of Analysis (COA) detailing exact concentration, solvent content, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area, away from heat and ignition sources. Due to its highly volatile and easily oxidized nature, the solution should be handled and transferred using standard Schlenk or cannula techniques under an inert atmosphere to maintain purity and safety.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (Titration)	0.50 M in THF (± 0.05 M)
Assay (as Grignard Reagent)	≥ 95%
Solvent (THF)	Balance
Identification (IR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.