Description

4-Bromofluorobenzene is a versatile halogenated aromatic building block essential for advanced organic synthesis. Its unique combination of bromine and fluorine substituents makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for coupling reactions and as a precursor to various functionalized aromatics.

Application

• Pharmaceutical Intermediate: A key starting material in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring fluorinated or brominated aromatic cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Lithiation & Functionalization: The bromine atom allows for directed ortho-metalation, enabling the introduction of a wide range of other functional groups onto the benzene ring.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new synthetic pathways in organofluorine chemistry.

Basic Information

Product Name	4-Bromofluorobenzene
CAS No.	460-00-4
Molecular Formula	C6H4BrF
Molecular Weight	175.00 g/mol
Synonyms	1-Bromo-4-fluorobenzene; p-Bromofluorobenzene; 4-Fluorobromobenzene; 4-Fluorophenyl bromide; p-Fluorobromobenzene; 4-Fluoro-1-bromobenzene; (4-Fluorophenyl)bromide; Fluorobenzene, 4-bromo-
EINECS	207-310-0

Quality Control

Our 4-Bromofluorobenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.49 g/mL
Boiling Point	~152-154 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.