Description

1-Bromo-4-(Fluoromethyl)-Benzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and a fluoromethyl substituent on a benzene ring, makes it a critical precursor for introducing functional complexity into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and specialty materials requiring specific halogenated motifs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluoromethyl group can enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Acts as a precursor in the manufacture of fluorinated compounds for electronic displays and optical devices.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of fluorinated charge-transport or emissive materials for high-performance OLED displays.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Stille couplings to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine introduction on the physical and chemical properties of aromatic compounds.

Basic Information

Product Name	1-Bromo-4-(Fluoromethyl)-Benzene
CAS No.	459-49-4
Molecular Formula	C7H6BrF
Molecular Weight	189.03 g/mol
Synonyms	4-Bromobenzyl Fluoride; α-Fluoro-4-Bromotoluene; p-Bromobenzyl Fluoride; (4-Bromophenyl)fluoromethane; 1-Bromo-4-(fluoromethyl)benzene; 4-Bromo-α-fluorotoluene; Fluoromethyl-p-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Fluoromethyl)-Benzene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.5 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.