Description

2-Fluoro-5-Nitropyridine is a versatile fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a fluorine atom, makes it an invaluable intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the development of modern pesticides, herbicides, and fungicides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The fluorine atom is readily displaced by various nucleophiles, enabling the introduction of diverse functional groups.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for drug discovery and lead optimization.

Basic Information

Product Name	2-Fluoro-5-Nitropyridine
CAS No.	456-24-6
Molecular Formula	C5H3FN2O2
Molecular Weight	142.09 g/mol
Synonyms	5-Nitro-2-fluoropyridine; 2-Fluoro-5-nitropyridine; 2-Fluoropyridine-5-nitropyridine; 5-Nitro-2-fluoro-pyridine; Fluoronitropyridine; Pyridine, 2-fluoro-5-nitro-; 2-Fluoro-5-nitro-pyridin; 456-24-6 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.