Description

1-(1-Chloroethyl)-4-Fluorobenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a benzylic chlorine and a fluorine substituent, makes it a critical intermediate for constructing complex molecules. This compound is primarily needed by research and development laboratories and production facilities in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can improve biological activity and environmental persistence.
• Liquid Crystal Materials: Acts as a building block for fluorinated components in liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and stability.
• Organic Electronics: Employed in the development of materials for organic light-emitting diodes (OLEDs) and semiconductors due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed reactions, such as Suzuki or Negishi couplings, to create biaryl structures.
• Chemical Research: Utilized in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	1-(1-Chloroethyl)-4-Fluorobenzene
CAS No.	456-16-6
Molecular Formula	C8H8ClF
Molecular Weight	158.60 g/mol
Synonyms	1-(1-Chloroethyl)-4-fluorobenzene; 4-Fluoro-α-(chloromethyl)toluene; 1-Chloro-1-(4-fluorophenyl)ethane; p-Fluoro-α-(chloromethyl)toluene; (1-Chloroethyl)-4-fluorobenzene; 4-Fluorobenzyl chloride, α-methyl-; 1-(4-Fluorophenyl)ethyl chloride; α-Chloro-4-fluoroethylbenzene
EINECS	Contact for details

Quality Control

Our 1-(1-Chloroethyl)-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.