Description

Methyl 5-Fluoropyridine-3-Carboxylate is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing both the fluoropyridine and ester functionalities into target molecules, enabling the development of compounds with enhanced biological activity and physicochemical properties. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluoropyridine moiety can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and organic semiconductors, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated heterocycles.

Basic Information

Product Name	Methyl 5-Fluoropyridine-3-Carboxylate
CAS No.	455-70-9
Molecular Formula	C7H6FNO2
Molecular Weight	155.13 g/mol
Synonyms	5-Fluoro-3-pyridinecarboxylic acid methyl ester; Methyl 5-fluoro-3-pyridinecarboxylate; 3-Pyridinecarboxylic acid, 5-fluoro-, methyl ester; 5-Fluoronicotinic acid methyl ester; Methyl 5-fluoronicotinate; 455-70-9; 5-Fluoropyridine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Fluoropyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.