Description

(Difluoromethyl)Benzene CAS NO 455-31-2 is a versatile fluorinated aromatic building block characterized by its high volatility. This compound is essential for introducing the difluoromethyl group into complex molecules, a key modification in modern synthetic chemistry. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for applications ranging from medicinal chemistry to specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluoromethyl moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a key precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and as a reagent for difluoromethylation in academic and industrial research laboratories.
• Polymer & Resin Modifier: Imparts unique properties such as increased chemical resistance, altered solubility, and enhanced thermal stability to specialty polymers and epoxy resins.

Basic Information

Product Name	(Difluoromethyl)Benzene
CAS No.	455-31-2
Molecular Formula	C7H6F2
Molecular Weight	128.12 g/mol
Synonyms	Benzylidene Difluoride; α,α-Difluorotoluene; Difluoromethylbenzene; (Difluoromethyl)benzene; Benzyl Difluoride; Phenyl(difluoro)methane; Toluene, α,α-difluoro-; EINECS 207-250-6
EINECS	207-250-6

Quality Control

Our (Difluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including GC, NMR, and Karl Fischer titration to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and maintain product integrity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	1.14 - 1.16 g/mL
Refractive Index (n20D)	1.470 - 1.474

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.