Description

Benzenesulfonyl Fluoride, 4-Acetyl- is a versatile and highly reactive chemical intermediate, specifically a sulfonyl fluoride derivative. Its core value lies in its ability to act as a key building block in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for researchers and manufacturers in the fine chemical, life sciences, and material science industries who require a reliable and high-purity reagent for advanced synthetic applications.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive sulfonyl fluoride group.
• Chemical Biology & Proteomics: Acts as a reactive probe in activity-based protein profiling (ABPP) to study enzyme function and discover new drug targets.
• Material Science Research: Employed in the creation of specialized polymers and advanced materials with unique surface properties.
• Cross-Coupling Reactions: Functions as an electrophile in palladium-catalyzed and other metal-mediated cross-coupling reactions to form carbon-sulfur bonds.
• Sulfonamide Library Synthesis: A key starting material for generating diverse libraries of sulfonamide compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Benzenesulfonyl Fluoride, 4-Acetyl-
CAS No.	455-25-4
Molecular Formula	C8H7FO3S
Molecular Weight	202.20 g/mol
Synonyms	4-Acetylbenzenesulfonyl Fluoride; 1-(4-Fluorosulfonylphenyl)ethanone; p-Acetylbenzenesulfonyl Fluoride; 4-Acetylphenylsulfonyl Fluoride; Ethanone, 1-[4-(fluorosulfonyl)phenyl]-; 4-Acetylbenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our Benzenesulfonyl Fluoride, 4-Acetyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.