Description

4-(Chloromethyl)Benzenesulphonyl Fluoride is a versatile and highly reactive organosulfur compound that serves as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a chloromethyl and a sulfonyl fluoride group, makes it an invaluable reagent for introducing the benzenesulfonyl moiety and for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the development of sulfonamide-based drugs, polymer modifiers, and covalent enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide drugs, including protease inhibitors, diuretics, and antibacterial agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with sulfonyl fluoride activity.
• Chemical Biology & Proteomics: Used as a reactive handle in activity-based protein profiling (ABPP) and for developing covalent inhibitors targeting specific enzymes.
• Polymer & Material Science: Monomer or cross-linking agent for modifying polymer backbones to impart specific chemical resistance or surface properties.
• Ligand & Catalyst Development: Intermediate for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Fluorination Reagent: Source of the sulfonyl fluoride group for late-stage fluorosulfonylation reactions in medicinal chemistry.

Basic Information

Product Name	4-(Chloromethyl)Benzenesulphonyl Fluoride
CAS No.	455-21-0
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	p-(Chloromethyl)benzenesulfonyl Fluoride; α-Chloro-p-toluenesulfonyl Fluoride; 4-(Chloromethyl)phenylsulfonyl Fluoride; (4-Chloromethylphenyl)sulfonyl Fluoride; Benzenesulfonyl Fluoride, 4-(chloromethyl)-; 1-(Chloromethyl)-4-(fluorosulfonyl)benzene; p-Chloromethylphenyl Sulfonyl Fluoride; Tosyl Fluoride, 4-Chloromethyl Derivative
EINECS	Contact for details

Quality Control

Our production of 4-(Chloromethyl)Benzenesulphonyl Fluoride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure consistency and reliability. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing the product meets your specified research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.