Description

p-Ethylbenzenesulphonyl Fluoride is a specialized organosulfur compound featuring a sulfonyl fluoride functional group. This reactive moiety makes it a valuable building block and reagent in advanced chemical synthesis, particularly for creating sulfonamides and other sulfonyl derivatives. It is primarily utilized by pharmaceutical intermediates manufacturers and agrochemical research and development teams.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides that incorporate sulfonyl functional groups for enhanced activity.
• Chemical Biology & Proteomics: Serves as a reactive probe in activity-based protein profiling (ABPP) to label and study serine hydrolases and other enzymes.
• Material Science: Employed in the modification of polymer surfaces and the creation of specialty monomers with sulfonyl fluoride handles for further functionalization.
• Cross-coupling Reagent: Acts as an electrophilic coupling partner in palladium-catalyzed and other metal-mediated cross-coupling reactions to form carbon-sulfur bonds.
• Sulfonylation Agent: Used to introduce the sulfonyl fluoride group into other molecules, which can then be further derivatized into sulfonamides, sulfonate esters, or sulfonic acids.

Basic Information

Product Name	p-Ethylbenzenesulphonyl Fluoride
CAS No.	455-20-9
Molecular Formula	C8H9FO2S
Molecular Weight	188.22 g/mol
Synonyms	4-Ethylbenzenesulfonyl Fluoride; p-Ethylphenylsulfonyl Fluoride; 1-Ethyl-4-(fluorosulfonyl)benzene; 4-Ethylbenzene-1-sulfonyl Fluoride; Benzenesulfonyl fluoride, 4-ethyl-; Ethylbenzenesulfonyl Fluoride (para-isomer)
EINECS	Contact for details

Quality Control

Our p-Ethylbenzenesulphonyl Fluoride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems support compliance with cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.