Description

1-Fluoro-4-(Trimethylsilyl)Benzene is a high-value organosilicon intermediate featuring both a fluorine atom and a trimethylsilyl group on a benzene ring. This unique structure makes it a versatile building block for introducing fluorinated aromatic moieties into more complex molecules, particularly in advanced material science and pharmaceutical research. It is essential for chemists and R&D teams in the agrochemical, pharmaceutical, and specialty polymer industries who require precise functionalization for developing novel compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of fluorinated drug candidates, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the fluorinated aromatic ring enhances biological activity and environmental persistence.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic semiconductors.
• Cross-Coupling Reactions: Employed in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactivity of the silicon group.
• Organic Synthesis Building Block: Utilized for introducing both fluorine and silicon protecting groups in complex multi-step synthetic routes.
• Research & Development: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and silicon chemistry.

Basic Information

Product Name	1-Fluoro-4-(Trimethylsilyl)Benzene
CAS No.	455-17-4
Molecular Formula	C9H13FSi
Molecular Weight	168.28 g/mol
Synonyms	p-Fluorophenyltrimethylsilane; 4-Fluorophenyltrimethylsilane; (4-Fluorophenyl)trimethylsilane; Trimethyl(4-fluorophenyl)silane; 1-Fluoro-4-trimethylsilylbenzene; 4-Fluoro-1-(trimethylsilyl)benzene; F-TMS-Benzene; 455-17-4
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-(Trimethylsilyl)Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and assay. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality system is designed to meet the stringent requirements of research and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.