Description

p-Toluenesulfonyl Fluoride is a versatile and highly reactive organosulfur compound widely used as a selective fluorinating and sulfonylating agent. Its primary value lies in its ability to act as a stable, shelf-stable precursor for generating reactive intermediates in complex organic syntheses, particularly in the development of pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists working in medicinal chemistry, where it serves as a key building block for creating sulfonamides and other functionalized molecules. Its reliable reactivity profile makes it a critical reagent for fine chemical manufacturers targeting high-value, specialized products.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for the preparation of sulfonamide drugs, including protease inhibitors and antibacterial agents.
• Peptide Chemistry: Used as a protecting group for amines during solid-phase peptide synthesis (SPPS) and other complex peptide coupling reactions.
• Agrochemical Development: Serves as a key intermediate in the synthesis of modern herbicides, fungicides, and plant growth regulators.
• Material Science: Employed in the surface modification of polymers and the creation of specialty monomers with sulfonyl fluoride functionalities.
• Chemical Biology Probes: Utilized in activity-based protein profiling (ABPP) and the development of covalent inhibitors for target identification and validation.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed cross-coupling reactions to form carbon-sulfur bonds.

Basic Information

Product Name	p-Toluenesulfonyl Fluoride
CAS No.	455-16-3
Molecular Formula	C7H7FO2S
Molecular Weight	174.19 g/mol
Synonyms	4-Methylbenzenesulfonyl Fluoride; Tosyl Fluoride; p-Tolylsulfonyl Fluoride; Toluene-4-sulfonyl Fluoride; 4-Toluenesulfonyl Fluoride; PTSF; Ts-F; TosF
EINECS	207-247-0

Quality Control

Our p-Toluenesulfonyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is subjected to comprehensive analytical testing including HPLC, GC, NMR, and Karl Fischer titration. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	44 - 48 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.