Description

Benzenesulfonyl Fluoride, 3-(Aminocarbonyl)- is a specialized aromatic sulfonyl fluoride derivative, also known as 3-Carbamoylbenzenesulfonyl fluoride. This compound serves as a key chemical building block and reactive intermediate in advanced organic synthesis, valued for its unique combination of a sulfonyl fluoride warhead and an amide functional group. It is primarily utilized by pharmaceutical research and agrochemical development teams for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of protease inhibitors, kinase inhibitors, and other small molecule drug candidates, leveraging the sulfonyl fluoride moiety for covalent binding.
• Chemical Biology Probe: Used in activity-based protein profiling (ABPP) to label and study serine hydrolases and other enzymes in complex biological systems.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides and fungicides with enhanced efficacy and selectivity.
• Material Science: Employed in the modification of polymer surfaces and the creation of specialty monomers for advanced materials.
• Cross-coupling Reactions: Acts as a coupling partner in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to introduce the sulfonyl fluoride functional group into complex molecules.
• Library Synthesis for Drug Discovery: Used in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	Benzenesulfonyl Fluoride, 3-(Aminocarbonyl)-
CAS No.	454-94-4
Molecular Formula	C7H6FNO3S
Molecular Weight	203.19 g/mol
Synonyms	3-Carbamoylbenzenesulfonyl Fluoride; m-Carbamoylbenzenesulfonyl Fluoride; 3-Aminocarbonylbenzenesulfonyl Fluoride; Benzoic acid, 3-(fluorosulfonyl)-, amide; 3-(Fluorosulfonyl)benzamide; 454-94-4; BSF-3-CA
EINECS	Contact for details

Quality Control

Our Benzenesulfonyl Fluoride, 3-(Aminocarbonyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.