Description

3-Methylbenzenesulfonyl Fluoride is a versatile organosulfur reagent featuring a reactive sulfonyl fluoride group. This compound is valued for its role as a key building block and chemical modifier in advanced organic synthesis and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures and developing novel chemical probes.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide derivatives and other bioactive molecules.
• Chemical Biology & Proteomics: Used as a covalent probe in activity-based protein profiling (ABPP) to study enzyme function and identify drug targets due to its selective reactivity.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of herbicides, fungicides, and other crop protection agents.
• Polymer & Material Science: Employed as a monomer or cross-linking agent for producing specialty polymers with unique surface properties.
• Organic Synthesis Reagent: Acts as a sulfonylating agent for introducing the tosyl (Ts) protecting group or for facilitating various nucleophilic substitution reactions.
• Dye & Pigment Manufacturing: Utilized in the synthesis of sulfonated dyes and colorants.

Basic Information

Product Name	3-Methylbenzenesulfonyl Fluoride
CAS No.	454-66-0
Molecular Formula	C7H7FO2S
Molecular Weight	174.19 g/mol
Synonyms	m-Toluenesulfonyl Fluoride; 3-Toluenesulfonyl Fluoride; m-Tosyl Fluoride; 3-Methylbenzenesulfonyl Fluoride; m-Methylbenzenesulfonyl Fluoride; Benzenesulfonyl fluoride, 3-methyl-; Tosyl Fluoride, meta-substituted
EINECS	207-238-6

Quality Control

Our 3-Methylbenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications and supporting your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and amines. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.