Description

1,1,1-Trifluoro-3-Nitropropan-2-Ol CAS NO 453-35-0 is a versatile fluorinated nitro alcohol building block, prized for its unique trifluoromethyl and nitro functional groups. This compound is essential for introducing fluorine atoms and nitro handles into target molecules, significantly altering their physical, chemical, and biological properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel compounds with enhanced activity, stability, or bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in the development of protease inhibitors, anti-inflammatory agents, and CNS-active molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Organic Synthesis Reagent: Serves as a versatile precursor for nucleophilic substitution reactions, Henry reactions (nitroaldol), and the preparation of other fluorinated intermediates like amines and amino alcohols.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic materials where fluorine incorporation modifies surface energy and dielectric properties.
• Chemical Biology & Proteomics: Useful as a probe or labeling agent due to the reactivity of the nitro group, which can be reduced to an amine for further conjugation.

Basic Information

Product Name	1,1,1-Trifluoro-3-Nitropropan-2-Ol
CAS No.	453-35-0
Molecular Formula	C₃H₄F₃NO₃
Molecular Weight	159.06 g/mol
Synonyms	2-Nitro-1,1,1-trifluoro-2-propanol; 1,1,1-Trifluoro-2-hydroxy-3-nitropropane; 3-Nitro-1,1,1-trifluoropropan-2-ol; 2-Propanol, 1,1,1-trifluoro-3-nitro-; α-(Trifluoromethyl)-β-nitroethanol; TFN; TFPNO
EINECS	Contact for details

Quality Control

Our production of 1,1,1-Trifluoro-3-Nitropropan-2-Ol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support compliance with cGMP and ISO standards for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.