Description

4-Fluoro-3-Iodotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both fluorine and iodine substituents on a toluene backbone, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in cross-coupling reactions like Suzuki-Miyaura and Buchwald-Hartwig amination.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers.
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination and functional group transformation methodologies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.

Basic Information

Product Name	4-Fluoro-3-Iodotoluene
CAS No.	452-82-4
Molecular Formula	C7H6FI
Molecular Weight	236.03 g/mol
Synonyms	1-Fluoro-2-iodo-4-methylbenzene; 3-Iodo-4-fluorotoluene; 2-Iodo-1-fluoro-4-methylbenzene; 4-Methyl-3-iodofluorobenzene; 4-Fluoro-3-iodo-1-methylbenzene; Toluene, 4-fluoro-3-iodo-; 452-82-4
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Iodotoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Handle and store under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.