Description

3-Fluoro-4-Iodotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on a toluene backbone, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and iodinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the halogen atoms are crucial for biological activity and binding affinity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis, such as cross-coupling reactions.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and advanced polymers where halogenated aromatics influence electronic properties and self-assembly.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Stille couplings), enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry Studies: Acts as a model substrate for investigating the influence of fluorine atoms on aromatic substitution patterns and reaction kinetics.

Basic Information

Product Name	3-Fluoro-4-Iodotoluene
CAS No.	452-79-9
Molecular Formula	C7H6FI
Molecular Weight	236.03 g/mol
Synonyms	1-Fluoro-2-iodo-4-methylbenzene; 4-Methyl-3-fluoro-1-iodobenzene; 3-Fluoro-4-iodo-1-methylbenzene; 2-Fluoro-5-iodotoluene; 3-Fluoro-p-iodotoluene; 4-Iodo-3-fluorotoluene; Toluene, 3-fluoro-4-iodo-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Iodotoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, ensuring traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.