Description

2,4-Difluorotoluene CAS NO 452-76-6 is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the toluene ring, which significantly influences the electronic and steric properties of target molecules. This compound is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluoromethyl or difluoromethoxy groups.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a fundamental building block for fluorine-containing compounds used in electronic display technologies.
• Polymer & Resin Modification: Employed to introduce fluorine into polymer chains, improving chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Acts as a starting material for various cross-coupling reactions (e.g., Suzuki, Negishi) to create complex, fluorinated aromatic structures.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2,4-Difluorotoluene
CAS No.	452-76-6
Molecular Formula	C7H6F2
Molecular Weight	128.12 g/mol
Synonyms	1,3-Difluoro-4-methylbenzene; 2,4-Difluoro-1-methylbenzene; 4-Methyl-1,3-difluorobenzene; α,α,2,4-Tetrafluorotoluene (deprecated); 2,4-DFT; Toluene, 2,4-difluoro-; Benzene, 1,3-difluoro-4-methyl-
EINECS	207-207-5

Quality Control

Our 2,4-Difluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C (59°F and 77°F). Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Density (20°C)	1.15 - 1.18 g/mL
Refractive Index (n20D)	1.460 - 1.465

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.