Description

4-Chloro-2-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents on the toluene ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and stability.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic aromatic substitution to introduce functionalized aryl groups into target molecules.
• Polymer & Resin Modifier: Acts as a monomer or modifier in the production of specialty polymers, imparting specific chemical resistance or thermal properties.
• Dyestuff & Pigment Intermediate: Utilized in the synthesis of complex, halogenated dyes and pigments for high-performance applications.

Basic Information

Product Name	4-Chloro-2-Fluorotoluene
CAS No.	452-75-5
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	2-Fluoro-4-chlorotoluene; 1-Chloro-4-fluoro-2-methylbenzene; 4-Chloro-2-fluoro-1-methylbenzene; 2-Methyl-4-chlorofluorobenzene; Toluene, 4-chloro-2-fluoro-; 4-Chloro-o-fluorotoluene; 2-Fluoro-4-chloro-1-methylbenzene; 4-Chloro-2-fluoromethylbenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (20°C)	~1.22 g/cm³
Boiling Point	~185-190°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.