Description

2-Chloro-4-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on a toluene backbone, makes it a critical intermediate for introducing specific reactivity and electronic properties into target molecules. This compound is essential for manufacturers and R&D teams in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoromethyl or chlorotoluene moiety.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides, where its halogenated structure contributes to biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated organic compounds used in electronic displays and optoelectronic devices.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter physical properties such as thermal stability, chemical resistance, and refractive index.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic aromatic substitution reactions to construct complex molecular architectures.
• Dye & Pigment Intermediate: Acts as a starting material for the production of specialized fluorinated dyes and colorants.

Basic Information

Product Name	2-Chloro-4-Fluorotoluene
CAS No.	452-73-3
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	1-Chloro-2-fluoro-4-methylbenzene; 2-Chloro-4-fluoromethylbenzene; 4-Fluoro-2-chlorotoluene; 2-Chloro-4-methylfluorobenzene; o-Chloro-p-fluorotoluene; Toluene, 2-chloro-4-fluoro-; 2-Chloro-4-fluoro-1-methylbenzene; Benzene, 1-chloro-2-fluoro-4-methyl-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorotoluene is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, ensuring full traceability and compliance with your internal specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	≤ 1.0% (Total)
Density (20°C)	~1.20 g/cm³
Boiling Point	~185-188°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.