Description

2,5-Difluorotoluene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the toluene ring, which allows for precise modulation of electronic properties and metabolic stability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic motifs to enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and pesticides, where the difluorotoluene structure contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving their dielectric anisotropy and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter physical properties such as chemical resistance, thermal stability, and surface energy.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution reactions to introduce fluorinated phenyl groups.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating novel fluorinated compounds in academic and industrial R&D settings.

Basic Information

Product Name	2,5-Difluorotoluene
CAS No.	452-67-5
Molecular Formula	C7H6F2
Molecular Weight	128.12 g/mol
Synonyms	1,4-Difluoro-2-methylbenzene; 2-Methyl-1,4-difluorobenzene; α,α,2,5-Tetrafluorotoluene (incorrect but sometimes used); 2,5-Difluoromethylbenzene; Benzene, 1,4-difluoro-2-methyl-; 2,5-DFT
EINECS	Contact for details

Quality Control

Our 2,5-Difluorotoluene is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) for every batch, detailing purity, identity, and impurity profiles as determined by GC, HPLC, and NMR. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Density (20°C)	~1.15 g/cm³
Refractive Index (n20D)	~1.46

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.