Description

5-Chloro-2-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine substituents on the toluene ring, which enables precise molecular modifications and the introduction of specific physicochemical properties. This compound is primarily needed by R&D and production chemists in the pharmaceutical and agrochemical industries for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and chlorinated aromatic motifs.
• Agrochemical Synthesis: Used in the manufacturing of advanced herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display and lighting technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic aromatic substitution to create complex molecular architectures.
• Dye & Pigment Manufacturing: Acts as an intermediate for producing specialized halogenated dyes and colorants.
• Polymer Modification: Used to introduce halogenated phenyl groups into polymer chains to alter thermal and chemical resistance properties.

Basic Information

Product Name	5-Chloro-2-Fluorotoluene
CAS No.	452-66-4
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	2-Fluoro-5-chlorotoluene; 1-Chloro-4-fluoro-2-methylbenzene; 5-Chloro-2-fluoro-1-methylbenzene; 2-Methyl-4-chlorofluorobenzene; Toluene, 5-chloro-2-fluoro-; 4-Chloro-2-fluorotoluene (isomer); 452-66-4; 2-Fluoro-5-methylchlorobenzene
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluorotoluene is produced under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of industrial and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (20°C)	~1.22 g/cm³
Boiling Point	~185-190 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.