Description

2-Bromo-5-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms on the toluene ring, which allows for selective functionalization and the introduction of unique physicochemical properties into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and brominated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where the fluorine atom can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to the tuning of electronic properties and molecular alignment.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Functional Material Research: Employed in academic and industrial research to develop new polymers, ligands for catalysis, and advanced organic frameworks.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	2-Bromo-5-Fluorotoluene
CAS No.	452-63-1
Molecular Formula	C7H6BrF
Molecular Weight	189.03 g/mol
Synonyms	1-Bromo-2-fluoro-4-methylbenzene; 2-Fluoro-5-methylbromobenzene; 4-Methyl-2-fluorobromobenzene; 5-Fluoro-2-bromotoluene; 2-Bromo-5-fluoro-1-methylbenzene; o-Bromo-m-fluorotoluene; Toluene, 2-bromo-5-fluoro-
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-aligned synthesis and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.52 g/cm³
Boiling Point	~195-198 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.