Description

3-Bromo-4-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents on a toluene backbone, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and brominated aromatic systems for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogen atoms are crucial for biological activity and selectivity.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating fluorinated organic semiconductors and liquid crystal compounds used in display technologies.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form new carbon-carbon bonds.
• Organic Synthesis Research: Employed in academic and industrial R&D for exploring new reaction methodologies and synthesizing novel fluorinated compounds.
• Dye & Pigment Intermediate: Used in the manufacture of specialized dyes and pigments where halogen substitution modifies color properties and lightfastness.

Basic Information

Product Name	3-Bromo-4-Fluorotoluene
CAS No.	452-62-0
Molecular Formula	C7H6BrF
Molecular Weight	189.03 g/mol
Synonyms	1-Bromo-2-fluoro-4-methylbenzene; 2-Fluoro-4-methylbromobenzene; 4-Methyl-2-fluorobromobenzene; 3-Bromo-4-methylfluorobenzene; Toluene, 3-bromo-4-fluoro-; 4-Fluoro-3-bromotoluene; 2-Fluoro-4-bromotoluene
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluorotoluene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.5 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.