Description

2-Fluorophenylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry. Its primary value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, enabling the efficient synthesis of complex fluorinated aromatic compounds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries, where the introduction of a fluorophenyl moiety is a critical step in developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediates: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated aromatic rings, which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the 2-fluorophenyl group contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, polymers, and organic electronic materials to modify physical properties.
• Fine Chemical Production: Facilitates the introduction of the 2-fluorophenyl group into dyes, flavors, and fragrances.
• Academic & R&D Laboratories: A fundamental reagent for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Product Name	2-Fluorophenylmagnesium Bromide
CAS No.	446-53-7
Molecular Formula	C6H4FMgBr
Molecular Weight	199.30 g/mol
Synonyms	o-Fluorophenylmagnesium Bromide; (2-Fluorophenyl)magnesium Bromide; Magnesium, bromo(2-fluorophenyl)-; 2-Fluorophenyl Grignard Reagent; 2-Fluorobenzene, bromomagnesio-; Bromo(2-fluorophenyl)magnesium; 1-Fluoro-2-(bromomagnesio)benzene
EINECS	Contact for details

Quality Control

Our 2-Fluorophenylmagnesium Bromide is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthesis. Quality is assured through comprehensive analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content. A Certificate of Analysis (COA) detailing concentration, purity, and identity is provided with each shipment. Our quality management system supports compliance with cGMP and ISO standards for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, easily oxidized, and reacts vigorously with protic solvents. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area, away from moisture, heat, and incompatible materials such as acids, water, and oxidizing agents. For optimal stability, storage at 2-8°C is recommended for extended periods. The container must be kept sealed and handled only under anhydrous conditions.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR / NMR)	Conforms to structure
Solvent Content	Balance (Specified solvent)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.