Description

o-Toluenesulfonyl Fluoride is a versatile organosulfur reagent featuring a sulfonyl fluoride functional group. This compound is valued for its role as a key building block and fluorinating agent in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is essential for researchers and manufacturers in fine chemical, pharmaceutical, and material science industries seeking to introduce sulfonyl or fluorine motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for creating sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides that incorporate sulfonyl fluoride groups for enhanced bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science: Employed in the surface modification of polymers and the synthesis of specialty monomers for advanced materials.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed and other metal-mediated cross-coupling reactions.
• Fluorination Agent: Provides a source of fluorine atoms in organic synthesis under mild conditions.

Basic Information

Product Name	o-Toluenesulfonyl Fluoride
CAS No.	444-31-5
Molecular Formula	C7H7FO2S
Molecular Weight	174.19 g/mol
Synonyms	2-Methylbenzenesulfonyl Fluoride; o-Tosyl Fluoride; 2-Toluenesulfonyl Fluoride; ortho-Toluenesulfonyl Fluoride; 2-Methylphenylsulfonyl Fluoride; Toluene-2-sulfonyl Fluoride; o-TsF; 2-TsF
EINECS	207-150-9

Quality Control

Our o-Toluenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	38 - 42 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.