Description

2-Nitro-Benzenesulfonyl Fluoride is a versatile and reactive organosulfur compound that serves as a key building block in advanced chemical synthesis. Its primary value lies in its role as a selective sulfonylation and fluorination reagent, enabling the efficient construction of complex molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drugs and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides requiring sulfonyl fluoride motifs.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Material Science: Employed in the creation of specialty polymers and advanced materials with specific surface functionalities.
• Organic Synthesis Reagent: Acts as a robust electrophile for introducing the sulfonyl fluoride group into aromatic and heteroaromatic systems under mild conditions.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions for constructing biaryl sulfones, important scaffolds in medicinal chemistry.

Basic Information

Product Name	2-Nitro-Benzenesulfonyl Fluoride
CAS No.	433-98-7
Molecular Formula	C6H4FNO4S
Molecular Weight	205.16 g/mol
Synonyms	o-Nitrobenzenesulfonyl Fluoride; 2-Nitrobenzenesulfonyl Fluoride; Benzenesulfonyl fluoride, 2-nitro-; NSC 404080; 2-Nitrobenzene-1-sulfonyl fluoride; ortho-Nitrobenzenesulfonyl fluoride
EINECS	207-105-8

Quality Control

Our 2-Nitro-Benzenesulfonyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.