Description

Trifluoromethanesulfonyl Chloride (CAS NO 421-83-0) is a highly reactive and versatile fluorinated sulfonyl chloride intermediate. Its primary value lies in its powerful triflating ability, enabling the efficient introduction of the robust trifluoromethanesulfonyl (triflyl) group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a key building block for creating advanced materials and active ingredients.

Application

• Pharmaceutical Synthesis: A critical reagent for preparing trifluoromethanesulfonate (triflate) esters, which are excellent leaving groups in cross-coupling reactions (e.g., Suzuki, Negishi) for constructing complex drug molecules.
• Agrochemical Intermediates: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the stability and lipophilicity imparted by the triflyl group.
• Polymer & Material Science: Employed to synthesize specialty monomers and polymers, including high-performance resins and materials with unique surface properties.
• Catalyst & Ligand Preparation: Key for manufacturing metal-organic catalysts and chiral ligands used in asymmetric synthesis.
• Organic Synthesis Reagent: Acts as a strong electrophile and triflating agent in various organic transformations, including Friedel-Crafts acylations and the synthesis of sulfonamides.
• Fluorine Chemistry Research: A fundamental building block in academic and industrial research focused on developing new fluorinated compounds with tailored properties.

Basic Information

Product Name	Trifluoromethanesulfonyl Chloride
CAS No.	421-83-0
Molecular Formula	CClF3O2S
Molecular Weight	168.52 g/mol
Synonyms	Triflic Chloride; Trifluoromethanesulphonyl Chloride; Trifluoromethylsulfonyl Chloride; Perfluoromethanesulfonyl Chloride; CF3SO2Cl; TfCl; NSC 9225
EINECS	207-017-0

Quality Control

Our Trifluoromethanesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases, alcohols, and amines. Due to its highly volatile and moisture-sensitive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.