Description

2-Phenylethene-1-Sulfonyl Fluoride is a versatile and reactive chemical building block, specifically a sulfonyl fluoride derivative of styrene. Its primary value lies in its role as a key intermediate in the synthesis of more complex molecules, particularly through sulfur(VI) fluoride exchange (SuFEx) click chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require a reliable, high-purity reagent for constructing sulfonate esters and sulfonamides, enabling the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, especially those containing sulfonamide or sulfonate ester moieties with potential biological activity.
• SuFEx Click Chemistry Reagent: Serves as a robust electrophile in Sulfur(VI) Fluoride Exchange reactions, enabling the efficient, modular, and reliable construction of chemical libraries for drug discovery and material science.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the sulfonyl fluoride group can be transformed into bioactive sulfonamides.
• Polymer & Material Science: Employed as a monomer or cross-linking agent to introduce reactive sites or specific functional groups into polymers, coatings, and advanced materials.
• Chemical Biology Probes: Utilized in the development of activity-based probes for studying enzyme function and profiling proteomes due to its specific reactivity with certain amino acid residues.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies and CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Item	Detail
Product Name	2-Phenylethene-1-Sulfonyl Fluoride
CAS No.	405-18-5
Molecular Formula	C8H7FO2S
Molecular Weight	186.20 g/mol
Synonyms	Styryl sulfonyl fluoride; Vinylphenyl sulfonyl fluoride; (E)-2-Phenylethenesulfonyl fluoride; (E)-Styrenesulfonyl fluoride; β-Styrenesulfonyl fluoride; 1-(Ethenesulfonyl)-2-fluorobenzene; 2-Phenylethenesulfonyl fluoride; Phenylvinylsulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 2-Phenylethene-1-Sulfonyl Fluoride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our commitment to reliable supply and traceability supports your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize exposure to moisture and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.