Description

6-Fluoronicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a carboxylic acid and a fluorine substituent on the pyridine ring, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of fluorinated organic electronic materials and liquid crystals.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products for metabolic and mechanistic studies.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and fine chemical companies performing bespoke synthesis.

Basic Information

Product Name	6-Fluoronicotinic Acid
CAS No.	403-45-2
Molecular Formula	C6H4FNO2
Molecular Weight	141.10 g/mol
Synonyms	2-Fluoro-5-pyridinecarboxylic Acid; 5-Carboxy-2-fluoropyridine; 6-Fluoropyridine-3-carboxylic Acid; 3-Carboxy-2-fluoropyridine; Nicotinic acid, 6-fluoro-; 2-Fluoronicotinic Acid (common numbering); 6-Fluoro-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Fluoronicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.