Description

4-(Trifluoromethyl)Benzyl Bromide is a versatile and highly reactive organobromine compound, serving as a critical building block in advanced organic synthesis. Its value lies in the combination of the reactive benzyl bromide moiety and the electron-withdrawing trifluoromethyl group, which imparts unique physicochemical properties to target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated aromatic structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylated aromatic rings to enhance metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the CF₃ group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Employed in the production of fluorinated compounds for electronic displays and organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and catalysts used in cross-coupling reactions and asymmetric synthesis.
• Polymer Modification: Used to introduce fluorinated benzyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorinated compounds and reaction methodologies.

Basic Information

Product Name	4-(Trifluoromethyl)Benzyl Bromide
CAS No.	402-49-3
Molecular Formula	C₈H₆BrF₃
Molecular Weight	239.04 g/mol
Synonyms	α-Bromo-4-(trifluoromethyl)toluene; (4-(Trifluoromethyl)phenyl)methyl bromide; 1-(Bromomethyl)-4-(trifluoromethyl)benzene; p-(Trifluoromethyl)benzyl bromide; 4-(Trifluoromethyl)phenylmethyl bromide; 4-CF3-Benzyl Bromide; p-CF3C6H4CH2Br
EINECS	206-941-5

Quality Control

Our 4-(Trifluoromethyl)Benzyl Bromide is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature and reactivity, it is recommended to store under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.